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Skip to content Dept. Molecular Oncology   Professor Kozo TANAKA, MD, PhD Assistant Professor Kenji IEMURA Assistant Professor Kinue KUNIYASU The Department of Molecular Oncology focuses on the mechanisms of mitotic regulation in relation to oncogenesis and anti-cancer therapy. Our body is made up with sixty trillion cells as a result of proliferation of one fertilized egg. In each cell of our body, 46 chromosomes are properly transmitted. On the other hand, cancer is characterized by unrestricted proliferation of cells and most of the cancer cells show abnormalities in the number of chromosomes and structure due to chromosomal instability, which is an increased rate of chromosome missegregation in mitosis. Chromosomal instability is not just a result of oncogenic transformation, but it is supposedly closely related to oncogenesis and cancer progression, although its detailed mechanism is elusive. Thus, we are aiming to contribute to the elucidation of the mechanisms of oncogenesis and its resistance to anti-cancer drugs; and furthermore, predict the effects of drugs on individual patients and to develop a new strategy for anti-cancer therapy. Research Topics: •Mechanism of proper chromosome segregation in human cells. •Mechanism of cell death by anti-mitotic drugs. •Mechanism of oncogenesis derived from chromosomal abnormality. •Process of chromosome capture by microtubules observed by live-cell imaging. •Mechanism of mitotic regulation in budding yeast.   About Us IDAC’s Mission Statement Greeting &#038; Mission Notable Alumni History of IDAC IDAC&#8217;s Affiliations News &#038; Events Research Facilities &#038; Faculty Research Facilities Common Facilities Resources &#038; Equipment Brain Imaging Cell Center Equipment Admission &#038; Courses Mechanisms of Aging Overcoming Intractable Cancers Overcoming Age-Related Brain Diseases Achieving &#8220;Smart-Aging&#8221; Public Relations &#038; Info. Office Maps &#038; Directions Give to IDAC Contact Us Privacy Policy &#038; Disclaimer IDAC COVID-19 Update Navi About Us IDAC’s Mission Statement Greeting &#038; Mission Notable Alumni History of IDAC IDAC&#8217;s Affiliations News &#038; Events Research Facilities &#038; Faculty Research Facilities Common Facilities Resources &#038; Equipment Brain Imaging Cell Center Equipment Admission &#038; Courses Mechanisms of Aging Overcoming Intractable Cancers Overcoming Age-Related Brain Diseases Achieving &#8220;Smart-Aging&#8221; Public Relations &#038; Info. Office Maps &#038; Directions Give to IDAC Contact Us Privacy Policy &#038; Disclaimer IDAC COVID-19 Update Navi ©Institute of Development, Aging and Cancer, Tohoku University

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